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ID 116784
Title Alternative
樹状細胞はニッケルアレルギーの発症時にニッケルイオンを抗原として直接認識する
Author
Liu, Lipei Tokushima University
Yunizar, Mohammad Fadyl Tokushima University
Keywords
Metal allergy
Nickel ions
Phagocytosis
Dendritic cell migration
Content Type
Thesis or Dissertation
Description
Metal hypersensitivity, a disorder of the immune system, typically manifests as contact hypersensitivity to metals during daily contact. The molecular mechanism whereby metals enter the body and cause allergic disorders remains elusive. It is thought that eluted metal ions are captured by dendritic cells (DCs) and transferred to the draining lymph nodes to activate T cells. Here, for the first time, we used a metal indicator Newport Green to locate the most common allergenic metal, nickel (Ni) ions, captured by DCs and transferred to lymph nodes. Capturing Ni ions did not affect the activity of DCs. Ni ions entered DCs and showed positive staining in keratinocytes. A time varied quantitative analysis demonstrated that at 1 h, a small amount of Ni ions was observed in the epidermal sheet. After 6 h, the number of Ni ions that entered the epidermal sheet reached a peak and remained constant for a few days and were gradually emitted 48 h later. In the cervical lymph nodes of mice, accumulation of Ni ions reached a peak within 24 h and then gradually decreased. The findings of this study will contribute to the development of effective diagnoses and treatment methods for patients allergic to Ni.
Journal Title
Journal of Oral Health and Biosciences
ISSN
21896682
Publisher
四国歯学会
Volume
34
Issue
2
Start Page
40
End Page
52
Sort Key
40
Published Date
2022-03-06
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Lipei Liuの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3586号
Diploma Number
甲口第481号
Granted Date
2022-03-10
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
University Hospital
Oral Sciences