ID | 111508 |
Author |
Aoki, Rika
Kagawa Prefectural Cancer Detection Center
Yasuda, Mitsugi
Kagawa Prefectural Cancer Detection Center
Torisu, Ryusuke
Kagawa Prefectural Cancer Detection Center
Nakamoto, Jiro
Kagawa Prefectural Cancer Detection Center
Yamamoto, Yosuke
Kagawa Prefectural Cancer Detection Center
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Keywords | gastric carcinomas
lymph node metastasis
gastric-phenotype
E-cadherin
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Content Type |
Journal Article
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Description | Background : Recent advances in immunohistochemical staining have led to the proposition of a classification of gastric carcinomas based on cellular phenotypes, and the degree of biological malignancy of gastric-phenotype carcinomas has attracted particular attention.
Subjects and Methods : One hundred and seven submucosal (SM) invasive carcinomas encountered in our center were examined for their histological type, cellular phenotype, and E-cadherin expression status to clarify their relationships with lymph node metastasis. Results : Eleven (10.3%) of 107 SM gastric carcinomas were lymph node metastasis-positive. Gastric-phenotype carcinomas accounted for 20.6%, with a lymph node metastasis rate of 27.3% (6/22), which was significantly higher (p<0.05) than those of intestinal-phenotype carcinomas (5.9%) and mixed-phenotype carcinomas (2.9%). In terms of E-cadherin expression, only carcinomas with reduced E-cadherin expression showed lymph node metastasis at a rate significantly higher than that of carcinomas with normal E-cadherin expression (p<0.05). The lymph node metastasis rate (46.2%) of gastric-phenotype carcinomas with reduced E-cadherin expression was significantly higher than those of carcinomas of other phenotypes (p<0.05). Conclusion : Since gastric-phenotype differentiated carcinomas with reduced E-cadherin expression have the potential for becoming undifferentiated, the risk of lymph node metastasis should be considered. |
Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA11166929
AA12022913
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Publisher | Faculty of Medicine Tokushima University
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Volume | 54
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Issue | 1-2
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Start Page | 159
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End Page | 167
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Sort Key | 159
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Published Date | 2007-02
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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