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ID 110260
Title Transcription
セイカツ シュウカンビョウ ト タンパク ニョウ CKD ヨウセイ ヒンド ニ カンスル リンショウテキ ケントウ : トクニ ケッチュウ シボウサン ブンカク トノ カンレン ニツイテ
Title Alternative
A clinical study on life-related disease and the positive frequency of proteinuria : in the relation concernig the fraction of serum fatty acids
Author
Mitani, Hiroaki Mitani Clinic
Keywords
metabolic syndrome
CKD
polyunsaturated fatty acid
Content Type
Journal Article
Description
In recent years, it was markedly noticed that metabolic syndrome were related with chronic kidney disease(CKD), and then out of 349 medical mass examination 159 participants(age : 66.9 ±9.4 y. o)were examined clinical parameters, such as BMI, Waist obesity, TG, HDL-C, LDL-C, FPG, F-IRI, HOMA-IR, Adiponectin, Leptin, as the serum fraction of polyunsaturated fatty acids(DHLA, AA, EPA, DHA), in admission spotty proteinuria, serum creatinine and GFR were estimated respectively. Positive proteinuria group were allowed the high frequency of HT, MetS and elevated HOMA-IR, especially male were lowed AA/EPA, GFR was significantly related with age and SP, what’s more obesity indicated HT, low HDL-C, high TG, elevated HONA-IR, low adiponecin high Leptin, high EPA high DHA. Moreover HbA1c ≧5.4 groups observed high incidence of HT, MetS and proteinuria, besides HT significantly observed each of the obesity, MetS, elevated HOMA-IR, low Adipo, high Leptin, elevated DHLA and declined GFR. Systolic blood pressure were suggested the positive relation to age, obesity, HOMA-IR, Leptin, DHLA, EPA, but A/L, GFR negatively. Clinical characteristics of MetS were high HOMA-IR, low Adipo, high Leptin, elevated DHLA, high frequency of proteinuria and lowered GFR in male. From above results, MetS was strongly related to CKD, it was thought that spotty proteinuria were suggested the detection of endothelial cell injury on early stage of glomerulosclerosis to be concerned in the metabolism of PUFAs.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
64
Issue
5-6
Start Page
242
End Page
251
Sort Key
242
Published Date
2008-12-20
FullText File
language
jpn
TextVersion
Publisher