| ID | 110373 |
| Title Transcription | チョクセツ サヨウガタ コウウイルスヤク DAAs ニヨル Cガタ マンセイ カンシッカン シンリョウ
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| Title Alternative | Antiviral therapy for chronic hepatitis C by means of direct acting anti-viral drugs
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| Author |
Tamori, Akihiro
Department of Hepatology, Osaka City University Graduate School of Medicine
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| Keywords | Chronic liver diseases
DAAs
HCV
interferon free therapy
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| Content Type |
Journal Article
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| Description | Hepatitis C virus（HCV）infection is a major worldwide health problem. Chronic infection induces continuous inflammation in the liver, progression of hepatic fibrosis, eventual cirrhosis, and possible hepatocellular carcinoma. Eradication of the virus is one of the most important treatment aims. A number of promising new direct-acting antivirals（DAAs）have been developed over the past １０ years. Due to their increased efficacy, safety, and tolerability, interferon-free oral therapies with DAAs have been approved for patients with HCV, including those with cirrhosis. This review introduces the characteristics and results of recent clinical trials of several DAAs : NS３/４ A protease inhibitors, NS５A inhibitors, and NS５B inhibitors. DAA treatment failure and prognosis after DAA therapy are also discussed.
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| Journal Title |
四国医学雑誌
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| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 72
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| Issue | 1-2
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| Start Page | 9
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| End Page | 12
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| Sort Key | 9
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| Published Date | 2016-04-25
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| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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