メサンギウム細胞増殖に関する新たな制御因子と病変抑止に関する研究

Mesangial proliferation is a common feature of many glomerular diseases, therefore, understanding the regulatory mechanism is important for the treatment of glomerular diseases. The present study showed growth arrest gene-6 (Gas6) is a new autocrine growth factor of mesangial cells and warfarin inhibited mesangial proliferation by inhibiting γ-carboxylation of Gas 6 in vitro and in vivo. We also found vitamin D anlog (22-oxa-calcitriol) is a new growth regulator for mesangial cells in vivo. These results indicate that these compounds have considerable potential for use as therapeutic strategy in the treatment of progressive glomerular disease.