ID | 110564 |
Title Transcription | ナゼ アレルギー シッカン ワ ゾウカ シテ イルノカ : メンエキガク ノ タチバ ヨリ
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Title Alternative | What increases allergic diseases in recent years? : from the view of immunology
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Author |
Tsukumo, Shin-ichi
Department of Immunology amp Parasitology, The University of Tokushima School of Medicine
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Hisaeda, Hajime
Department of Immunology amp Parasitology, The University of Tokushima School of Medicine
Yasutomo, Koji
Department of Immunology amp Parasitology, The University of Tokushima School of Medicine
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Keywords | type I allergy
IgE
Th2
mast cell
infection
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Content Type |
Journal Article
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Description | Type I allergic diseases, such as rhinitis, pollinosis and bronchial asthma, are mediated by Th2-type helper T cell induction, specific IgE antibody production and mast cell activation. Increases of these allergic diseases in recent years might be caused by skewed differentiation of T cells toward Th2 cells by some environmental factors including diesel exhaust particles and decreases of virus and bacteria infection in childhood. The decrease of parasite infection is also thought to affect the susceptibility against allergic diseases by eliciting polyclonal IgE production that suppresses mast cell activation. Important clues for prevention and therapy of the allergic diseases would be derived from further investigations of the relationship between the diseases and these environmental factors.
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Journal Title |
四国医学雑誌
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ISSN | 00373699
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NCID | AN00102041
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Publisher | 徳島医学会
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Volume | 58
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Issue | 6
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Start Page | 265
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End Page | 266
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Sort Key | 265
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Published Date | 2002-12-25
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FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
Medical Sciences
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