転移性臍癌（Sister Mary Joseph’s nodule）の2例

The nodular umbilical metastasis of the visceral carcinoma has been termed the “SisterMary Joseph’s nodule” (SMJN), and is one of signs of a terminal condition. There are variousroutes of metastasis according to anatomical and embryological specificity. We reporttwo cases of metastatic adenocarcinoma of the umbilicus, and also reviewed the 108 cases ofSNJN that have been reported in Japan.The patients were 49 year-old man and 84 year-old woman who were referred to ourhospital with umbilical nodules. Examination by computed tomographies, a biopsy and anextirpation of umbilical nodules showed that the primary malignancies were the pancreascancer and the gallbladder cancer.Of 110 SMJN cases in Japan, thirty-one were men and seventy-six were women, and theprimary focus was found in the stomach (45/103 : 39%), ovarium (18/103 : 13%), pancreas (14/103 : 15%) or colon (11/103 : 12%). In fifty-two cases (52/94 : 55%), initial presentation of theinternal organ carcinoma was an umbilical nodule.It is generally reported that the prognosis of the patient with SMJN is extremely poor,but a few cases get the long survival after extirpation of SMJN. In order to decide propertreatment and prognosis, it is necessary us to further examine the primary malignancy andthe route of metastasis for the SMJN patient.