| ID | 110617 |
| Title Transcription | シボウ サイボウ ノ カガク
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| Title Alternative | Science of adipose tissue
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| Author |
Nakaya, Yutaka
Department of Nutrition, The University of Tokushima School of Medicine
Tokushima University Educator and Researcher Directory
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Matsushima, Rie
Department of Nutrition, The University of Tokushima School of Medicine
Morishima, Masaki
Department of Nutrition, The University of Tokushima School of Medicine
Harada, Nagakatu
Department of Nutrition, The University of Tokushima School of Medicine
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| Keywords | adipocytokines
adiponectin
fat tissue
tumor necrosis factor
plasminogen activator inhibitor-1
atherosclerosis
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| Content Type |
Journal Article
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| Description | Adipose tissue secretes a variety of bioactive molecules (adipocytokines) that directlycontribute to the development of life-style related diseases, such as diabetes, hypertension,and cardiovascular diseases. TNF-α is a well - known inhibitor of insulin signaling and PAI(plasminogen activator inhibitor) - 1 contributes to thrombus formation. Adiponectin has anaction both insulin sensitivity and anti - atherogenic action. Interestingly, low plasmaadiponectin concentrations were observed in patients with obesity, coronary artery disease(CAD), and type 2 diabetes. Adiponectin from the plasma adhered to the injured arteryand suppressed the endothelial expression of adhesion molecules, the proliferation ofvascular smooth muscle cells, and the transformation of macrophage to foam cells. Thesefindings support that accumulation of fat produces not only insulin resistance but alsoatherosclrosis in obese subjects.
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| Journal Title |
四国医学雑誌
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| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 59
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| Issue | 4-5
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| Start Page | 211
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| End Page | 213
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| Sort Key | 211
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| Published Date | 2003-10-25
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| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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| departments |
University Hospital
Medical Sciences
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