ID | 111269 |
Author |
Watanabe, Masanari
Tottori University
Kurai, Jun
Tottori University
Minato, Sayaka
Tottori Prefectural Institute of Health and Environment
Noma, Hisashi
Institute of Statistical Mathematics
Sano, Hiroyuki
Kindai University
Saito, Rumiko
Tohoku University
Aiba, Setsuya
Tohoku University
Oshimura, Mitsuo
Tottori University
Hatakeyama, Keisuke
Tottori Prefectural Institute of Health and Environment
Yamasaki, Akira
Tottori University
Shimizu, Eiji
Tottori University
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Keywords | particulate matter
pro-inflammatory cytokine
interleukin-8
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Content Type |
Journal Article
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Description | Background : Airborne particulate matter (PM) may stimulate production of pro-inflammatory cytokines, and thus exposure to PM affects pulmonary diseases. However, the effects of PM on pulmonary diseases have differed among studies. Methods : PM was collected from February 2 to 28 (winter) and June 1 to 17 (summer) in 2013 in Yurihama, Japan, using filters to separate particles with different aerodynamic diameters (1.1 to< 2.2 μm, 2.2 to< 3.3 μm, 3.3 to< 7.0 μm, and 7.0 to< 10 μm). Interleukin (IL)-8 transcriptional activity in THP-G8 cells was examined in response to winter and summer PM with different diameters. Results : IL-8 transcriptional activity induced by winter PM was significantly higher than that with summer PM for each diameter. For winter PM, IL-8 activity increased with an increased diameter, whereas this activity did not differ between a solvent control and each summer PM diameter. This indicates that summer PM does not stimulate production of IL-8 in THP-G8 cells. Conclusion : The effects of PM on production of pro-inflammatory cytokines differ with the season and PM diameter. This suggests that the compositions of PM differ on season, and the evaluation of compositions of PM is important in understanding the association of health with short-term exposure to PM.
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Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA11166929
AA12022913
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Publisher | Faculty of Medicine Tokushima University
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Volume | 62
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Issue | 3-4
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Start Page | 145
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End Page | 148
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Sort Key | 145
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Published Date | 2015-08
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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