| ID | 111338 |
| Author |
Koyama, Noriko
Asahi University
Hayashi, Toru
Asahi University
Gresik, Edward W
The City University of New York Medical School
Kashimata, Masanori
Asahi University
|
| Keywords | α6 integrin
Branching morphogenesis
Cleft formation
Stalk elongation
Submandibular gland
|
| Content Type |
Journal Article
|
| Description | The submandibular gland (SMG) of the fetal mouse is a well-studied model for the epithelial-mesenchymal interactions required for branching morphogenesis (BrM), which involves cleft formation and stalk elongation. In a previous report, we showed that α6 integrin subunit is involved in BrM of this gland rudiment, since the neutralizing antibody against α6 integrin subunit, GoH3, strongly inhibited branching of cultured intact E13 SMG. In this study, we investigated whether GoH3 inhibits cleft formation and/ or stalk elongation during BrM of cultured mesenchyme-free epithelial rudiments of fetal SMG and also analyzed by Western blotting the levels of phosphorylation of ERK1/2, which is a signaling molecule known to regulate BrM of the fetal mouse SMG.
|
| Journal Title |
The Journal of Medical Investigation
|
| ISSN | 13496867
13431420
|
| NCID | AA11166929
AA12022913
|
| Publisher | Faculty of Medicine Tokushima University
|
| Volume | 56
|
| Issue | Supplement
|
| Start Page | 247
|
| End Page | 249
|
| Sort Key | 247
|
| Published Date | 2009-12
|
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
