Dipyridamoleによる5’－DFURの増強効果の検討

This study was performed to investigate if dipyridamole (DP) had an enhancement effect on antitumor activity of 5'-deoxy-5-fluorouridine (5'-DFUR). The effect of 5'-DFUR by concomitant use of DP was studied on SCC-25 cells, FRO cells and KB cells in vitro using mainly the MTT assay. The effect of combined administration of 5'-DFUR and DP on L-cells was also examined.
No clear enhancing effect of DP on the antitumor activity of 5'-DFUR was found in FRO cells or KB cells, and a tendency toward decreased the activity of 5'-DFUR was found by concomitant use of DP. In SCC-25 cells, in contrast, the antitumor activity of 5'-DFUR was significantly enhanced by concomitant use of DP. In addition, a growth inhibitory effect of 5'-DFUR on L-cells was significantly suppressed by simultaneous treatment with DP.
These results suggest that DP may enhance the antitumor effect of 5'-DFUR on squamous cell carcinoma, which is the main cancer tissue type in the field of otorhinolaryngology, and suppress the adverse effect of 5'-DFUR on normal cells.