Total for the last 12 months
number of access : ?
number of downloads : ?
ID 112361
Title Alternative
尿中IV型コラーゲン排泄は非糖尿病日本人一般住民の推定糸球体濾過量の低下に関与する : 5年間の観察研究
Urinary type IV collagen excretion in the Japanese general population without diabetes
Author
Kishi, Fumi Tokushima University
Takamatsu, Norimichi Kawashima Hospital
Koezuka, Yasuhiko HuBit Genomix Inc.
Minagawa, Naoto HuBit Genomix Inc.
Ichien, Go HuBit Genomix Inc.
Keywords
Urinary type IV collagen
eGFR
without diabetes
Japanese general population
Chronic Kidney Desease
Content Type
Thesis or Dissertation
Description
Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted. The decline in estimated glomerular filtration rate (eGFR) was calculated. In participants with eGFR ≥80 mL/min, abnormal U-Col4 excretion was indicated as a significant independent risk factor for 10% eGFR change per year, which is one of the prognostic factors for the development of end-stage kidney disease. Moreover, in contrast to urinary albumin excretion, U-Col4 excretion was not related to age or kidney function, suggesting that some individuals with abnormal U-Col4 excretion can have an independent hidden risk for the development of kidney dysfunction. In conclusion, it is important to measure U-Col4 excretion in the general population without diabetes to determine changes in renal features in every individual and help detect future complications such as diabetic kidney disease. If U-Col4 excretion is abnormal, kidney manifestation should be carefully followed up, even if the kidney function and urinalysis findings are normal.
Journal Title
PLOS ONE
ISSN
19326203
Publisher
PLOS
Volume
13
Issue
4
Start Page
e0195523
Published Date
2018-04-06
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Fumi Kishiの学位論文として提出され,学位審査・授与の対象となっている。
Rights
Copyright: © 2018 Kishi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.( https://creativecommons.org/licenses/by/4.0/ )
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3197号
Diploma Number
甲医第1372号
Granted Date
2018-05-24
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences