ID | 113035 |
Title Alternative | FMD, PWV, and Cardiovascular Events
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Author |
Maruhashi, Tatsuya
Hiroshima University
Soga, Junko
Hiroshima University
Fujimura, Noritaka
Hiroshima University
Idei, Naomi
Hiroshima University
Mikami, Shinsuke
Hiroshima University
Iwamoto, Yumiko
Hiroshima University
Iwamoto, Akimichi
Hiroshima University
Kajikawa, Masato
Hiroshima University
Matsumoto, Takeshi
Hiroshima University
Oda, Nozomu
Hiroshima University
Kishimoto, Shinji
Hiroshima University
Matsui, Shogo
Hiroshima University
Hashimoto, Haruki
Hiroshima University
Aibara, Yoshiki
Hiroshima University
Yusoff, Farina Mohamad
Hiroshima University
Hidaka, Takayuki
Hiroshima University
Kihara, Yasuki
Hiroshima University
Chayama, Kazuaki
Hiroshima University
Noma, Kensuke
Hiroshima University
Nakashima, Ayumu
Hiroshima University
Goto, Chikara
Hiroshima International University
Tomiyama, Hirofumi
Tokyo Medical University
Takase, Bonpei
National Defense Medical College
Kohro, Takahide
Tokyo Medical University
Suzuki, Toru
University of Leicester
Ishizu, Tomoko
University of Tsukuba
Ueda, Shinichiro
University of the Ryukyu
Yamazaki, Tsutomu
The University of Tokyo
Furumoto, Tomoo
Hokkaido University
Kario, Kazuomi
Jichi Medical University
Inoue, Teruo
Dokkyo Medical University
Koba, Shinji
Showa University
Watanabe, Kentaro
Yamagata University
Takemoto, Yasuhiko
Osaka City University
Hano, Takuzo
Wakayama Medical University
Sata, Masataka
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Ishibashi, Yutaka
Shimane University
Node, Koichi
Saga University
Maemura, Koji
Nagasaki University
Ohya, Yusuke
University of the Ryukyus
Furukawa, Taiji
Teikyo University
Ito, Hiroshi
Okayama University
Ikeda, Hisao
Teikyo University
Yamashina, Akira
Tokyo Medical University
Higashi, Yukihito
Hiroshima University
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Keywords | arterial stiffness
coronary artery disease
endothelial function
flow-induced dilation
pulse wave velocity
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Content Type |
Journal Article
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Description | Background
The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. Methods and Results We measured flow‐mediated vasodilation (FMD) and brachial–ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow‐up period of 49.2 months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver‐operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06–0.74; P=0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09–0.79; P=0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01–3.44; P=0.04) and second (hazard ratio, 2.19; 95% confidence interval, 1.23–3.90; P=0.008) primary outcomes. Among 4 groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed. Conclusions In patients with coronary artery disease, both FMD and baPWV were significant predictors of cardiovascular events. The combination of FMD and baPWV provided further cardiovascular risk stratification. |
Journal Title |
Journal of the American Heart Association
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ISSN | 20479980
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Publisher | The American Heart Association|Wiley
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Volume | 7
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Issue | 14
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Start Page | e008588
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Published Date | 2018-07-12
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Rights | Copyright © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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language |
eng
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departments |
Medical Sciences
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