Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis

Kudo, Yasusei; Iizuka, Shinji; Yoshida, Maki; Tsunematsu, Takaaki; Kondo, Tomoyuki; Subarnbhesaj, Ajiravudh; Deraz, Elsayed M.; Siriwardena, Samadarani B. S. M.; Tahara, Hidetoshi; Ishimaru, Naozumi; Ogawa, Ikuko; Takata, Takashi

doi:10.1074/jbc.M112.373159

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ID	113581
Title Alternative	MMP-13 Promotes Tumor Angiogenesis
Author	Kudo, Yasusei Hiroshima University\|The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers Iizuka, Shinji Hiroshima University Yoshida, Maki Hiroshima University Tsunematsu, Takaaki Hiroshima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Kondo, Tomoyuki The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers Subarnbhesaj, Ajiravudh Hiroshima University Deraz, Elsayed M. Hiroshima University Siriwardena, Samadarani B. S. M. Hiroshima University Tahara, Hidetoshi Hiroshima University Ishimaru, Naozumi The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers Ogawa, Ikuko Hiroshima University Takata, Takashi Hiroshima University
Content Type	Journal Article
Description	Background: Angiogenesis is an important step in the metastatic cascade of tumors. Results: MMP-13 itself as well as VEGF-A secretion from fibroblasts promotes angiogenesis. Indeed, MMP-13 is well correlated with blood vessel density in human cancer tissues. Conclusion: MMP-13 can be a marker for prediction of malignant behaviors and a therapeutic target in cancer. Significance: This work provides new insights regarding the role of MMP-13 in tumor angiogenesis.
Journal Title	Journal of Biological Chemistry
ISSN	1083351X
NCID	AA1202441X
Publisher	The American Society for Biochemistry and Molecular Biology
Volume	287
Issue	46
Start Page	38716
End Page	38728
Published Date	2012-09-19
Remark	This research was originally published in the Journal of Biological Chemistry. Yasusei Kudo, Shinji Iizuka, Maki Yoshida, Takaaki Tsunematsu, Tomoyuki Kondo, Ajiravudh Subarnbhesaj, Elsayed M. Deraz, Samadarani B. S. M. Siriwardena, Hidetoshi Tahara, Naozumi Ishimaru, Ikuko Ogawa, and Takashi Takata. Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis. J. Biol. Chem. 2012; Vol:287(46) pp.38716-38728.
Rights	© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
EDB ID	257374
DOI (Published Version)	10.1074/jbc.M112.373159
URL ( Publisher's Version )	https://doi.org/10.1074/jbc.M112.373159
FullText File	jbc_287_46_38716.pdf 2.77 MB
language	eng
TextVersion	Publisher
departments	Oral Sciences Medical Sciences