ID | 113584 |
Title Alternative | ROLE OF RUNX3 IN HEAD AND NECK CANCER
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Author |
Kudo, Yasusei
Hiroshima University
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Tsunematsu, Takaaki
Hiroshima University
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Takata, Takashi
Hiroshima University
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Keywords | RUNX3
ONCOGENE
HEAD AND NECK CANCER
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Content Type |
Journal Article
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Description | Cumulative evidences show that Runt-related transcription factor 3 (RUNX3) has a tumor suppressive role in various cancers. In particular, RUNX3 appears to be an important component of the transforming growth factor-beta (TGF-ß)-induced tumor suppression pathway. Contrary to reports on this tumor suppressive role of RUNX3, RUNX3 can also function as an oncogene when overexpressed. Recently, we found that RUNX3 overexpression was frequently observed and was well correlated with malignant behaviors in head and neck cancer, which is one of the most common types of human cancer. Moreover, it has been revealed that RUNX3 overexpression promoted cell growth and inhibited apoptosis in head and neck cancer cells. This review introduces the oncogenic role of RUNX3 in certain types of cancer including head and neck cancer.
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Journal Title |
Journal of Cellular Biochemistry
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ISSN | 07302312
10974644
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NCID | AA1052210X
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Publisher | Wiley-Liss
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Volume | 112
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Issue | 2
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Start Page | 387
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End Page | 393
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Published Date | 2010-12-06
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Rights | This is the peer reviewed version of the following article: Kudo, Y. , Tsunematsu, T. and Takata, T. (2011), Oncogenic role of RUNX3 in head and neck cancer. J. Cell. Biochem., 112: 387-393, which has been published in final form at https://doi.org/10.1002/jcb.22967. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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language |
eng
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Author
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departments |
Oral Sciences
Medical Sciences
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