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ID 113584
Title Alternative
ROLE OF RUNX3 IN HEAD AND NECK CANCER
Author
Takata, Takashi Hiroshima University
Keywords
RUNX3
ONCOGENE
HEAD AND NECK CANCER
Content Type
Journal Article
Description
Cumulative evidences show that Runt-related transcription factor 3 (RUNX3) has a tumor suppressive role in various cancers. In particular, RUNX3 appears to be an important component of the transforming growth factor-beta (TGF-ß)-induced tumor suppression pathway. Contrary to reports on this tumor suppressive role of RUNX3, RUNX3 can also function as an oncogene when overexpressed. Recently, we found that RUNX3 overexpression was frequently observed and was well correlated with malignant behaviors in head and neck cancer, which is one of the most common types of human cancer. Moreover, it has been revealed that RUNX3 overexpression promoted cell growth and inhibited apoptosis in head and neck cancer cells. This review introduces the oncogenic role of RUNX3 in certain types of cancer including head and neck cancer.
Journal Title
Journal of Cellular Biochemistry
ISSN
07302312
10974644
NCID
AA1052210X
Publisher
Wiley-Liss
Volume
112
Issue
2
Start Page
387
End Page
393
Published Date
2010-12-06
Rights
This is the peer reviewed version of the following article: Kudo, Y. , Tsunematsu, T. and Takata, T. (2011), Oncogenic role of RUNX3 in head and neck cancer. J. Cell. Biochem., 112: 387-393, which has been published in final form at https://doi.org/10.1002/jcb.22967. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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DOI (Published Version)
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language
eng
TextVersion
Author
departments
Oral Sciences
Medical Sciences