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ID 113598
Title Alternative
Periostin as an Invasion-Promoting Factor in HNSCC
Periostin promotes invasion and anchorage-independent growth in head and neck cancer
Author
Ogawa, Ikuko Hiroshima University
Kitajima, Shojiro Hiroshima University
Kitagawa, Masae Hiroshima University
Kawai, Hidehiko Hiroshima University
Gaffney, Patrick M. University of Minnesota
Miyauchi, Mutsumi Hiroshima University
Takata, Takashi Hiroshima University
Keywords
Periostin
invasion
metastasis
head and neck cancer
anchorage-independent growth
Content Type
Journal Article
Description
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer. Typically HNSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. However, molecular mechanisms associated with invasion and metastasis of HNSCC remain poorly understood. Here we identified Periostin as an invasion promoting factor in HNSCC by comparing the gene expression profiles between parent HNSCC cells and a highly invasive clone. Indeed, Periostin overexpression promoted the invasion and anchorage independent growth both in vitro and in vivo in HNSCC cells. Moreover, Periostin overexpressing cells spontaneously metastasized to cervical lymph nodes and to the lung through their aggressive invasiveness in an orthotopic mouse model of HNSCC. Interestingly, Periostin was highly expressed in HNSCCs in comparison with normal tissues, and the level of Periostin expression was well correlated with the invasiveness of HNSCC cases. In summary, these findings suggest that Periostin plays an important role for invasion and anchorage independent growth in the metastatic process of HNSCC.
Journal Title
Cancer Research
ISSN
00085472
15387445
NCID
AA00598557
AA12004911
Publisher
The American Association for Cancer Research
Volume
66
Issue
14
Start Page
6928
End Page
6935
Published Date
2006-07-18
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Oral Sciences