IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain

Iwasa, Takuma; Afroz, Shaista; Inoue, Miho; Arakaki, Rieko; Oshima, Masamitsu; Raju, Resmi; Waskitho, Arief; Inoue, Masahisa; Baba, Otto; Matsuka, Yoshizo

doi:10.1016/j.neulet.2019.03.031

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ID	113686
Title Alternative	神経障害性疼痛における三叉神経筋内のIL-10とCXCL2
Author	Iwasa, Takuma Tokushima University Afroz, Shaista Tokushima University Inoue, Miho Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Arakaki, Rieko Tokushima University KAKEN Search Researchers Oshima, Masamitsu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Raju, Resmi Tokushima University Waskitho, Arief Tokushima University Inoue, Masahisa Tokushima Bunri University Baba, Otto Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Matsuka, Yoshizo Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	Orofacial pain Neuropathic pain Sensory ganglia Glial cell Cytokine Chemokine
Content Type	Thesis or Dissertation
Description	Many trigeminal neuropathic pain patients suﬀer severe chronic pain. The neuropathic pain might be related with cross-excitation of the neighboring neurons and satellite glial cell (SGCs) in the sensory ganglia and increasing the pain signals from the peripheral tissue to the central nervous system. We induced trigeminal neuropathic pain by infraorbital nerve constriction injury (IONC) in Sprague-Dawley rats. We tested cytokine (CXCL2 and IL-10) levels in trigeminal ganglia (TGs) after trigeminal neuropathic pain induction, and the eﬀect of direct injection of the anti-CXCL2 and recombinant IL-10 into TG. We found that IONC induced pain behavior. Additionally, IONC induced satellite glial cell activation in TG and cytokine levels of TGs were changed after IONC. CXCL2 levels increased on day 1 of neuropathic pain induction and decreased gradually, with IL-10 levels showing the opposite trend. Recombinant IL-10 or anti-CXCL2 injection into TG decreased pain behavior. Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain.
Journal Title	Neuroscience Letters
ISSN	03043940
NCID	AA11540956 AA00754925
Publisher	Elsevier
Volume	703
Start Page	132
End Page	138
Published Date	2019-03-20
Remark	内容要旨・審査要旨・論文本文の公開本論文は，著者Takuma Iwasaの学位論文として提出され，学位審査・授与の対象となっている。
Rights	© 2019 Elsevier B.V. All rights reserved.
EDB ID	350008
DOI (Published Version)	10.1016/j.neulet.2019.03.031
URL ( Publisher's Version )	https://doi.org/10.1016/j.neulet.2019.03.031
FullText File	k3317_abstract.pdf 150 KB k3317_review.pdf 76.3 KB k3317_fulltext.pdf 1.34 MB
language	eng
TextVersion	ETD
MEXT report number	甲第3317号
Diploma Number	甲口第449号
Granted Date	2019-06-13
Degree Name	Doctor of Dental Science
Grantor	Tokushima University
departments	Oral Sciences