| ID | 113736 |
| Author |
Ohigashi, Izumi
University of Tokushima
Tokushima University Educator and Researcher Directory
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Ohte, Yuki
University of Tokyo
Setoh, Kazuya
Kyoto University
Nakase, Hiroshi
University of Tokushima
Maekawa, Akiko
University of Tokushima
Kiyonari, Hiroshi
RIKEN Center
Hamazaki, Yoko
Kyoto University
Sekai, Miho
Kyoto University
Sudo, Tetsuo
Kyoto University
Tabara, Yasuharu
Kyoto University
Sawai, Hiromi
University of Tokyo
Omae, Yosuke
University of Tokyo
Yuliwulandari, Rika
YARSI University
Tanaka, Yasuhito
Nagoya City University
Mizokami, Masashi
National Center for Global Health and Medicine
Inoue, Hiroshi
University of Tokushima
Kasahara, Masanori
Hokkaido University
Minato, Nagahiro
Kyoto University
Tokunaga, Katsushi
University of Tokyo
Tanaka, Keiji
Tokyo Metropolitan Institute of Medical Science
Matsuda, Fumihiko
Kyoto University
Murata, Shigeo
University of Tokyo
Takahama, Yousuke
University of Tokushima
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|
| Content Type |
Journal Article
|
| Description | The Psmb11-encoded β5t subunit of the thymoproteasome, which is specifically expressed in cortical thymic epithelial cells (cTECs), is essential for the optimal positive selection of functionally competent CD8+ T cells in mice. Here, we report that a human genomic PSMB11 variation, which is detectable at an appreciable allele frequency in human populations, alters the β5t amino acid sequence that affects the processing of catalytically active β5t proteins. The introduction of this variation in the mouse genome revealed that the heterozygotes showed reduced β5t expression in cTECs and the homozygotes further exhibited reduction in the cellularity of CD8+ T cells. No severe health problems were noticed in many heterozygous and 5 homozygous human individuals. Long-term analysis of health status, particularly in the homozygotes, is expected to improve our understanding of the role of the thymoproteasome-dependent positive selection of CD8+ T cells in humans.
|
| Journal Title |
JCI Insight
|
| ISSN | 23793708
|
| Publisher | American Society for Clinical Investigation
|
| Volume | 2
|
| Issue | 10
|
| Start Page | e93664
|
| Published Date | 2017-05-18
|
| Rights | Open Access Journal
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Institute of Advanced Medical Sciences
|
