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ID 114708
Title Alternative
2型糖尿病血液透析患者のグリコアルブミンに対するアルブミン漏出の影響
Albumin leakage and glycoalbumin in patients with diabetes undergoing hemodialysis
Author
Ueda, Sayo Tokushima University
Yokota, Narushi Kawashima Hospital
Hirose, Daisuke Kawashima Hospital
Mori, Hiroaki Kawashima Hospital
Noma, Yoshihiko Kawashima Hospital
Minakuchi, Jun Kawashima Hospital
Keywords
Albumin
Hemodialysis
Glycated albumin
HbA1c
Content Type
Thesis or Dissertation
Description
Glycated albumin (GA) is recommended as a better glycemic indicator than HbA1c in patients undergoing hemodialysis, because red blood cell lifespan is generally faster than that in normal subjects and easily altered by blood loss and erythropoiesis-stimulating agent administration. However, GA can be also affected by protein loss in urine and hemodialysis fluid. Therefore, in this study, we investigated the effect of albumin leakage induced by hemodialysis on GA in a crossover manner. Nine patients undergoing hemodialysis with large or small amounts of albumin leakage were observed for nine months. Valuables indicating glycemic control, albumin and hemoglobin metabolism and nutritional status were evaluated. As a result, it was shown that albumin leakage could affect GA, but the effect was practically small considering the prescription of diabetic drugs. The correlation between HbA1c and blood glucose levels was similar with that between GA and blood glucose levels in our study. In conclusion, GA was a reliable indicator, even with the change of hemodialysis modality. The influence of clinically acceptable albumin leakage induced by hemodialysis on GA was negligible practically. We should recognize that the preferable glycemic indicator in patients undergoing hemodialysis depends on the hemoglobin and albumin metabolism of each patient.
Journal Title
Journal of Artificial Organs
ISSN
14347229
16190904
NCID
AA11283795
Publisher
Springer nature|The Japanese Society for Artificial Organs
Volume
22
Issue
3
Start Page
264
End Page
267
Published Date
2019-02-25
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Sayo Uedaの学位論文として提出され,学位審査・授与の対象となっている。
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10047-019-01097-4
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3362号
Diploma Number
甲医第1445号
Granted Date
2020-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences