ID | 115079 |
Title Alternative | Regeneration of complex oral organs
Cell differentiation and development
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Author |
Oshima, Masamitsu
Tokushima University|RIKEN Center for Developmental Biology
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Ogawa, Miho
RIKEN Center for Developmental Biology|Organ Technologies
Tsuji, Takashi
RIKEN Center for Developmental Biology|Organ Technologies
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Content Type |
Journal Article
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Description | The development of organoid techniques for regenerative therapy has progressed remarkably with the use of tissue-derived stem cells and pluripotent stem cells based on stem cell biology and tissue engineering technology. To realize whole-organ replacement therapy as next-generation regenerative medicine, it is expected that fully functional bioengineered organs can be reconstructed using an in vitro three-dimensional (3D) bioengineered organ germ and organoids by stem cell manipulation and self-organization. In this mini-review, we focused on substantial advances of 3D bioengineering technologies for the regeneration of complex oral organs with the reconstruction of 3D bioengineered organ germ using organ-inductive potential embryo-derived epithelial and mesenchymal cells. These bioengineering technologies have the potential for realization of future organ replacement therapy.
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Journal Title |
Current Opinion in Cell Biology
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ISSN | 09550674
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NCID | AA10753496
AA11524927
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Publisher | Elsevier
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Volume | 49
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Start Page | 84
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End Page | 90
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Published Date | 2017-12-28
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Rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
DOI (Published Version) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Oral Sciences
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