ID | 115151 |
Author |
Tomiyama, Hirofumi
Tokyo Medical University
Ishizu, Tomoko
University of Tsukuba
Kohro, Takahide
Jichi Medical University
Matsumoto, Chisa
Tokyo Medical University
Higashi, Yukihito
Hiroshima University
Takase, Bonpei
National Defense Medical College
Suzuki, Toru
University of Leicester
Ueda, Shinichiro
University of the Ryukyu
Yamazaki, Tsutomu
The University of Tokyo
Furumoto, Tomoo
Hokkaido University
Kario, Kazuomi
Jichi Medical University
Inoue, Teruo
Dokkyo Medical University
Koba, Shinji
Showa University
Takemoto, Yasuhiko
Osaka City University
Hano, Takuzo
Wakayama Medical University
Sata, Masataka
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Ishibashi, Yutaka
Shimane University
Node, Koichi
Saga University
Maemura, Koji
Nagasaki University
Ohya, Yusuke
University of the Ryukyus
Furukawa, Taiji
Teikyo University
Ito, Hiroshi
Okayama University
Yamashina, Akira
Tokyo Medical University
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Keywords | Hypertension
Endothelial function
Arterial stiffness
Atherosclerosis
Renal function
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Content Type |
Journal Article
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Description | Objectives: To examine the longitudinal mutual association between endothelial dysfunction and arterial stiffness, and also to determine which of the two variables was more closely associated with the progression of subclinical organ damage.
Methods: The brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (CIMT), estimated glomerular filtration rate, microalbuminuria and flow-mediated vasodilatation of the brachial artery (FMD) were measured three times at 1.5-year intervals in 674 Japanese patients receiving antihypertensive treatment. Results: The change of the baPWV during the study period was larger in the subjects with baseline FMD values in the lowest tertile as compared to those with baseline FMD values in the highest tertile. The change of the CIMT was smaller in the subjects with baseline baPWV values in the lowest tertile than in those with baseline baPWV values in the highest tertile. After the adjustment, the FMD value at the baseline was inversely associated with the baPWV at the end of the study period (beta = − 0.07, p = 0.01), although, the reverse association was not significant. The baPWV, but not the FMD value, at the baseline was associated with the CIMT (beta = 0.06, p = 0.04) measured at the end of the study period. Conclusions: In hypertension, endothelial dysfunction was associated with the progression of arterial stiffness, although the reverse association was not confirmed. The increased arterial stiffness rather than endothelial dysfunction may be more closely associated with the progression of atherosclerotic vascular damage, and the endothelial dysfunction-arterial stiffness-atherosclerosis continuum may be important in hypertension. |
Journal Title |
International Journal of Cardiology
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ISSN | 01675273
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NCID | AA10623832
AA11530930
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Publisher | Elsevier
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Volume | 253
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Start Page | 161
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End Page | 166
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Published Date | 2017-11-12
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Rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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