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ID 115522
Title Alternative
Fever and Total Mechanical Ventilation Time in Critically Ill Patients
Author
Park, Dong Won Hanyang University
Egi, Moritoki Kobe university
Chang, Youjin Chungbuk National University
Suh, Gee Young Sungkyunkwan University
Lim, Chae-Man University of Ulsan
Kim, Jae Yeol Chung-Ang University
Tada, Keiichi Hiroshima City Hospital
Matsuo, Koichi New Tokyo Hospital
Takeda, Shinhiro Nippon Medical School
Tsuruta, Ryosuke Yamaguchi University
Yokoyama, Takeshi Teine Keijinkai Hospital
Kim, Seon-Ok University of Ulsan
Koh, Younsuck University of Ulsan
Keywords
Body Temperature
Intensive Care Units
Mechanical Ventilation
Fever
Content Type
Journal Article
Description
This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study. We included mechanically ventilated patients for more than 24 hours from 10 Korean and 15 Japanese intensive care units (ICU), and recorded maximal body temperature under the support of mechanical ventilation (MAXMV). To assess the independent association of MAXMV with TVT, we used propensity-matched analysis in a total of 769 survived patients with medical or surgical admission, separately. Together with multiple linear regression analysis to evaluate the association between the severity of fever and TVT, the effect of MAXMV on ventilator-free days was also observed by quantile regression analysis in all subjects including non-survivors. After propensity score matching, a MAXMV ≥ 37.5°C was significantly associated with longer mean TVT by 5.4 days in medical admission, and by 1.2 days in surgical admission, compared to those with MAXMV of 36.5°C to 37.4°C. In multivariate linear regression analysis, patients with three categories of fever (MAXMV of 37.5°C to 38.4°C, 38.5°C to 39.4°C, and ≥ 39.5°C) sustained a significantly longer duration of TVT than those with normal range of MAXMV in both categories of ICU admission. A significant association between MAXMV and mechanical ventilator-free days was also observed in all enrolled subjects. Fever may be a detrimental factor to prolong TVT in mechanically ventilated patients. These findings suggest that fever in mechanically ventilated patients might be associated with worse mechanical ventilation outcome.
Journal Title
Journal of Korean Medical Science
ISSN
10118934
15986357
NCID
AA10730934
Publisher
The Korean Academy of Medical Sciences
Volume
31
Issue
12
Start Page
2033
End Page
2041
Published Date
2016-10-10
Rights
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences