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ID 116287
Title Alternative
低出力超音波パルスは坐骨神経部分結紮によって引き起こされる神経障害性疼痛をマクロファージ極性制御を介して改善する
Ultrasound Ameliorates Neuropathic Pain
Author
Liu, Yao Tokushima University
Xia, Linze Tokushima University
Keywords
Neuropathic pain
Low-intensity pulsed ultrasound
Macrophages
Anti-inflammation
Content Type
Thesis or Dissertation
Description
Inflammatory (M1-polarized) macrophages cause neuropathic pain (NP) after nerve injury through non-resolving neuroinflammation. However, increasing evidence suggests that converting M1 to anti-inflammatory M2 macrophages may rescue NP. In the present study, the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) was investigated in a partial sciatic nerve ligation (PSL)-induced NP model.
Materials and Methods: Abnormal pain sensation, such as tactile allodynia, was caused by PSL. Immediately after PSL induction, the mice were subjected to LIPUS treatment for 20 min/day for 7 days. LIPUS was used at an average intensity of 60 mW/cm2 and a frequency of 1.5 MHz.
Results: In the behavioral test, the LIPUS group showed a significant improvement in the PSL-induced hypersensitivity compared to the PSL group not exposed to LIPUS. We found an increasing number of M2 macrophages in the injured sciatic nerves after LIPUS exposure. LIPUS treatment decreased expression of pro-inflammatory microglial markers in spinal cord.
Conclusions: Our data suggest that LIPUS has an anti-nociceptive effect by increasing anti-inflammatory M2 macrophage and may be a suitable therapeutic candidate for NP.
Journal Title
Journal of Oral Health and Biosciences
ISSN
21896682
Publisher
四国歯学会
Volume
34
Issue
1
Start Page
11
End Page
18
Sort Key
11
Published Date
2021-09-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yao LIUの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3543号
Diploma Number
甲口第474号
Granted Date
2021-09-09
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences