ID | 116502 |
Author |
Morigaki, Ryoma
Tokushima University
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Mure, Hideo
Tokushima University
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Fujita, Koji
Tokushima University
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Matsuda, Taku
Tokushima University
Yamamoto, Yoko
Tokushima University
Nakataki, Masahito
Tokushima University
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Okahisa, Tetsuya
Tokushima University
Miyake, Kazuhisa
Tokushima University
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Kaji, Ryuji
Tokushima University
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Keywords | dystonia disorder
movement disorders
somatoform disorder
deep brain stimulation
neuronal plasticity
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Content Type |
Journal Article
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Description | The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery.
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Journal Title |
Brain Sciences
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ISSN | 20763425
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Publisher | MDPI
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Volume | 10
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Issue | 9
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Start Page | 636
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Published Date | 2020-09-15
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Rights | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
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