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ID 116551
Title Alternative
Multiparametric analysis for pharynx SCC
Author
Fujima, Noriyuki Hokkaido University|Global Institution for collaborative research and education
Shimizu, Yukie Hokkaido University
Yoshida, Daisuke Hokkaido University
Kano, Satoshi Hokkaido University
Mizumachi, Takatsugu Hokkaido University
Homma, Akihiro Hokkaido University
Yasuda, Koichi Global Institution for collaborative research and education|Hokkaido University
Onimaru, Rikiya Hokkaido University
Sakai, Osamu Boston University
Kudo, Kohsuke Hokkaido University|Global Institution for collaborative research and education
Shirato, Hiroki Global Institution for collaborative research and education|Hokkaido University
Keywords
Magnetic Resonance Imaging
Multiparametric Magnetic Resonance Imaging
Squamous Cell Carcinoma of Head and Neck
Treatment Outcome
Content Type
Journal Article
Description
Purpose : To predict local control / failure by a multiparametric approach using magnetic resonance (MR)-derived tumor morphological and functional parameters in pharynx squamous cell carcinoma (SCC) patients. Materials and Methods : Twenty-eight patients with oropharyngeal and hypopharyngeal SCCs were included in this study. Quantitative morphological parameters and intratumoral characteristics on T2-weighted images, tumor blood flow from pseudo-continuous arterial spin labeling, and tumor diffusion parameters of three diffusion models from multi-b-value diffusion-weighted imaging as well as patients’ characteristics were analyzed. The patients were divided into local control / failure groups. Univariate and multiparametric analysis were performed for the patient group division. Results : The value of morphological parameter of ‘sphericity’ and intratumoral characteristic of ‘homogeneity’ was revealed respectively significant for the prediction of the local control status in univariate analysis. Higher diagnostic performance was obtained with the sensitivity of 0.8, specificity of 0.75, positive predictive value of 0.89, negative predictive value of 0.6 and accuracy of 0.79 by multiparametric diagnostic model compared to results in the univariate analysis. Conclusion : A multiparametric analysis with MR-derived quantitative parameters may be useful to predict local control in pharynx SCC patients.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
68
Issue
3-4
Start Page
354
End Page
361
Sort Key
354
Published Date
2021-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher