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ID 117227
Author
Miki, Yoshimi The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Taketomi, Yoshitaka The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Kidoguchi, Yuh Tokyo Metropolitan Institute of Medical Science|Tokyo Denki University
Yamamoto, Kei Tokyo Metropolitan Institute of Medical Science|Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Muramatsu, Kazuaki Tokyo Denki University
Nishito, Yasumasa Tokyo Metropolitan Institute of Medical Science
Park, Jonguk National Institutes of Biomedical Innovation, Health and Nutrition
Hosomi, Koji National Institutes of Biomedical Innovation, Health and Nutrition
Mizuguchi, Kenji National Institutes of Biomedical Innovation, Health and Nutrition|Osaka University
Kunisawa, Jun National Institutes of Biomedical Innovation, Health and Nutrition
Soga, Tomoyoshi Keio University
Boilard, Eric Université Laval
Gowda, Siddabasave Gowda B. RIKEN
Ikeda, Kazutaka RIKEN
Arita, Makoto RIKEN|Keio University
Murakami, Makoto The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Content Type
Journal Article
Description
Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted phospholipase A2 (sPLA2-IIA) prevents bacterial infection by degrading bacterial membranes. Here, we show that, despite the restricted intestinal expression of sPLA2-IIA in BALB/c mice, its genetic deletion leads to amelioration of cancer and exacerbation of psoriasis in distal skin. Intestinal expression of sPLA2-IIA is reduced after treatment with antibiotics or under germ-free conditions, suggesting its upregulation by gut microbiota. Metagenome, transcriptome, and metabolome analyses have revealed that sPLA2-IIA deficiency alters the gut microbiota, accompanied by notable changes in the intestinal expression of genes related to immunity and metabolism, as well as in the levels of various blood metabolites and fecal bacterial lipids, suggesting that sPLA2-IIA contributes to shaping of the gut microbiota. The skin phenotypes in Pla2g2a–/– mice are lost (a) when they are cohoused with littermate WT mice, resulting in the mixing of the microbiota between the genotypes, or (b) when they are housed in a more stringent pathogen-free facility, where Pla2g2a expression in WT mice is low and the gut microbial compositions in both genotypes are nearly identical. Thus, our results highlight a potentially new aspect of sPLA2-IIA as a modulator of gut microbiota, perturbation of which affects distal skin responses.
Journal Title
JCI Insight
ISSN
23793708
Publisher
American Society for Clinical Investigation
Volume
7
Issue
2
Start Page
e152611
Published Date
2022-01-25
Rights
This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry