Effect of stereochemistry on the catalytic activity of flavopeptides

Total for the last 12 months

number of access : ? 件

number of downloads : ?

Use this link to cite this item : https://repo.lib.tokushima-u.ac.jp/117574

ID	117574
Author	Arakawa, Yukihiro Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Takechi, Nao Tokushima University Yamanomoto, Ken Tokushima University Minagawa, Keiji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Imada, Yasushi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	Flavin Peptide Aerobic oxidation DFT calculation
Content Type	Journal Article
Description	The original flavopeptide catalyst, 3-FlC2-L-Pro-L-Tyr-L-Asp-Ado-NH-PS (Fl-PepLLL), and its diastereomers including Fl-PepDDL, Fl-PepLDL, and Fl-PepDLL were synthesized to investigate the correlation between their catalytic activity and stereochemistry. The results and related computations showed the importance of intramolecular hydrogen bonds involving the Asp residue in their 4a-hydroperoxy forms for the catalysis.
Journal Title	Tetrahedron Letters
ISSN	00404039
NCID	AA00861801 AA11539822
Publisher	Elsevier
Volume	73
Start Page	153107
Published Date	2021-04-22
Rights	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID	374954
DOI (Published Version)	10.1016/j.tetlet.2021.153107
URL ( Publisher's Version )	https://doi.org/10.1016/j.tetlet.2021.153107
FullText File	tetlet_73_153107.pdf 1.61 MB
language	eng
TextVersion	Author
departments	Science and Technology Liberal Arts and Sciences