ID | 118488 |
Title Alternative | Home-based aerobic exercise and resistance training
|
Author |
Uchiyama, Kiyotaka
Keio University
Adachi, Keika
Keio University
Muraoka, Kaori
Keio University
Nakayama, Takashin
Keio University
Oshida, Takuma
Keio University
Yasuda, Marie
Keio University
Hishikawa, Akihito
Keio University
Minakuchi, Hitoshi
Keio University
Miyashita, Kazutoshi
Keio University
Tokuyama, Hirobumi
Keio University
Wakino, Shu
Keio University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Itoh, Hiroshi
Keio University
|
Keywords | Home-based exercise
Chronic kidney disease
Randomized controlled trial
Incremental shuttle walking test
Quality of life
|
Content Type |
Journal Article
|
Description | Background
The potential effects of aerobic and resistance training in patients with severe chronic kidney disease (CKD) are not fully elucidated. This study investigated the effects of a home-based exercise programme on physical functioning and health-related quality of life (HRQOL) in patients with Stage 4 CKD, equivalent to estimated glomerular filtration rate of 15–30 mL/min/1.73 m2. Methods Forty-six patients with Stage 4 CKD (median age, 73 years; 33 men) were randomly assigned to exercise (n = 23) and control (n = 23) groups. Exercise group patients performed aerobic exercise at 40–60% peak heart rate thrice weekly and resistance training at 70% of one-repetition maximum twice weekly at home for 6 months. Control patients received no specific intervention. Primary outcomes were distance in incremental shuttle walking test and HRQOL assessed using the Kidney Disease Quality of Life—Short Form questionnaire. Secondary outcomes included kidney function assessed with combined urea and creatinine clearance, urinary biomarkers, and anthropometric and biochemical parameters associated with CKD. Results Improvement in incremental shuttle walking test was significantly greater in the exercise group compared with controls (39.4 ± 54.6 vs. −21.3 ± 46.1; P < 0.001). Among Kidney Disease Quality of Life domains, significant mean differences were observed between the exercise group and the control group in work status, quality of social interaction, and kidney disease component summary outcomes (12.76 ± 5.76, P = 0.03; 5.97 ± 2.59, P = 0.03; and 4.81 ± 1.71, P = 0.007, respectively). There were greater reductions in natural log (ln)-transformed urinary excretion of liver-type fatty acid-binding protein, ln serum C-reactive protein, and acylcarnitine to free carnitine ratio in the exercise group compared with controls, with significant between-group differences of −0.579 ± 0.217 (P = 0.008), −1.13 ± 0.35 (P = 0.003), and −0. 058 ± 0.024 (P = 0.01), respectively. Conclusions Our 6 month home-based exercise programme improved aerobic capacity and HRQOL in patients with Stage 4 CKD, with possible beneficial effects on kidney function and CKD-related parameters. |
Journal Title |
Journal of Cachexia, Sarcopenia and Muscle
|
ISSN | 21906009
|
Publisher | John Wiley & Sons|The Society on Sarcopenia, Cachexia and Wasting Disorders
|
Volume | 12
|
Issue | 6
|
Start Page | 1789
|
End Page | 1802
|
Published Date | 2021-09-23
|
Rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
|
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
Medical Sciences
|