ID | 118943 |
Author |
Katsuma, Susumu
The University of Tokyo
Hirota, Kanako
The University of Tokyo
Matsuda-Imai, Noriko
The University of Tokyo
Fukui, Takahiro
The University of Tokyo
Muro, Tomohiro
The University of Tokyo
Nishino, Kohei
Tokushima University
Kosako, Hidetaka
Tokushima University
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Shoji, Keisuke
The University of Tokyo
Takanashi, Hideki
The University of Tokyo
Fujii, Takeshi
Setsunan University
Arimura, Shin-ichi
The University of Tokyo
Kiuchi, Takashi
The University of Tokyo
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Content Type |
Journal Article
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Description | Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori. Our study identifies a mechanism by which Wolbachia induce male killing of host progeny.
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Journal Title |
Nature Communications
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ISSN | 20411723
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NCID | AA12645905
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Publisher | Springer Nature
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Volume | 13
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Start Page | 6764
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Published Date | 2022-11-14
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Rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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DOI (Published Version) | |
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language |
eng
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Publisher
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departments |
Institute of Advanced Medical Sciences
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