| ID | 119671 |
| Author |
Sun, Chunzhao
Tokushima University
Inokuma, Tsubasa
Tokushima University
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Yamaoka, Yousuke
Hyogo Medical University
Akagi, Reiko
Yasuda Women’s University
|
| Content Type |
Journal Article
|
| Description | The total synthesis of 1,4a-di-epi-ent-pancratistatin, a novel stereoisomer of the anti-tumor Amaryllidaceae alkaloid pancratistatin, was achieved in 14 steps starting from D-mannitol. The construction of the pancratistatin skeleton involved conjugate addition of organocuprate to a nitrosoolefin, which was generated in situ from inosose oxime. This was followed by stereoselective reduction of the oxime to an amine and site-selective formylation. Biological evaluations revealed that the newly synthesized compounds exhibit cytotoxicity toward cancer cells and significant ferroptosis inhibitory activity. These compounds constitute a promising small-molecule library for the development of potent bioactive agents.
|
| Journal Title |
Chemical Communications
|
| ISSN | 1364548X
|
| NCID | AA11071130
AA12455105
|
| Publisher | The Royal Society of Chemistry
|
| Volume | 60
|
| Issue | 53
|
| Start Page | 6757
|
| End Page | 6760
|
| Published Date | 2024-06-06
|
| Remark | 論文本文は2025-06-06以降公開予定
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| language |
eng
|
| TextVersion |
その他
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| departments |
Pharmaceutical Sciences
|
