2型糖尿病患者のスポット尿中C‐ペプチドに関する臨床的検討

Recently, to be interesting metabolic syndrome with insulin resistance, spot urine C-peptide （U-CPR） were examined to be compared with age, BMI, incidence of hypertension and hyperlipidemia, HbA１c, and the duration of diabetes mellitus in medical check group and type ２ diabetes mellitus respectively. U-CPR levels of the former with obesity, hypertension and hyperTG-hypoHDL-Cnemia elevated markedly. In addition U-CPR levels was gradually decreased in type ２ diabetes mellitus, moreover insulin therapy group is clearly declined and then it was thought that lowered U-CPR group were needed insulin treatments to have admitted under ２０～３０μg/gCr. Since glimepiride were reported extrapancreatic effects, glibenclamide was compared with dose/day. The former indicated high U-CPR levels with obesity and short durations of diabetes mellitus, and what's more it was recognized negative correlation between that of diabetes mellitus and postprandial U-CPR levels.
From these results, it was thought that the evaluation of spot urine CPR levels was easily useful for researching pathogenesis to be concerned with insulin resistance.

四国医学雑誌 : http://www.tokushima-u.ac.jp/med/research/shikoku_acta_medica.html