ID 101823
Title Transcription
ストレス セイギョ イガク ノ カクリツ オ メザシテ : DNA チップ オ モチイタ ストレス ヒョウカ
Title Alternative
Application of DNA chip and bioinformatics in stress assessment
Author
Rokutan, Kazuhito Division of Stress Science, Course of Proteomics Medical Science, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
stress
stress-related genes
stress assessment
DNA chip
Content Type
Journal Article
Description
Stress is an essential response for all organisms to adapt new, hazardous environments
and is mediated by mutation, reconstitution, and transcription of distinct genes. In mammals,
stress response is regulated by complex neuro-endocrine-immune systems. Recently, RNA
splicing and cap-independent translation are suggested to be involved in stress responses by
facilitating the synthesis of novel stress-related gene products. The human genome project
and micoarray techniques make it possible to correctly evaluate complex stress response.
We have developed a DNA chip specifically designed to examine the expression profile of
stress-related genes in human peripheral leukocytes. This novel biomental technique is a
powerful tool to simply, objectively assess stress responses in healthy individuals and
patients with psychiatric disorders. The diagnostic system consisting of the DNA chip and
stress bioinfomatics may provide a new insight into the pathogenesis of stress-related
disorders.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
60
Issue
1-2
Start Page
28
End Page
32
Sort Key
28
Published Date
2004-05-25
Remark
FullText File
language
jpn
departments
Medical Sciences