ID 101823
タイトルヨミ
ストレス セイギョ イガク ノ カクリツ オ メザシテ : DNA チップ オ モチイタ ストレス ヒョウカ
タイトル別表記
Application of DNA chip and bioinformatics in stress assessment
著者
六反, 一仁 徳島大学大学院ヘルスバイオサイエンス研究部プロテオミクス医科学部門生体制御医学講座ストレス制御医学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
stress
stress-related genes
stress assessment
DNA chip
資料タイプ
学術雑誌論文
抄録
Stress is an essential response for all organisms to adapt new, hazardous environments
and is mediated by mutation, reconstitution, and transcription of distinct genes. In mammals,
stress response is regulated by complex neuro-endocrine-immune systems. Recently, RNA
splicing and cap-independent translation are suggested to be involved in stress responses by
facilitating the synthesis of novel stress-related gene products. The human genome project
and micoarray techniques make it possible to correctly evaluate complex stress response.
We have developed a DNA chip specifically designed to examine the expression profile of
stress-related genes in human peripheral leukocytes. This novel biomental technique is a
powerful tool to simply, objectively assess stress responses in healthy individuals and
patients with psychiatric disorders. The diagnostic system consisting of the DNA chip and
stress bioinfomatics may provide a new insight into the pathogenesis of stress-related
disorders.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
60
1-2
開始ページ
28
終了ページ
32
並び順
28
発行日
2004-05-25
備考
フルテキストファイル
言語
jpn
部局
医学系