ID 104975
Title Transcription
カプサイシン ノ サヨウ ト ソノ レセプター TRPV1 オヨビ ソレラ ト カンレン スル コガタ イチジ チカク ニューロン ノ ガイカン
Title Alternative
An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons
Author
Nakagawa, Hiroshi Tokushima University Hospital, Dentistry for Persons with Disabilities Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hiura, Akio Department of Oral Histology, The University of Tokushima, Institute of Health Bioscience KAKEN Search Researchers
Keywords
カプサイシン
ヒスタミン
痒み
TRPV1
Content Type
Journal Article
Description
The specific actions of capsaicin on the small primary afferent neurons with regard to neuogenic inflammation and plasma extravasation are examined in this review. First, a short history of the study of capsaicin is introduced from the viewpoint of the efferent function of capsaicin-sensitive nerve fibers. Agonist (resiniferatoxin) and antagonists (capsazepine and ruthenium red) of capsaicin are refened, to better understand the action of the drug. The significance of the discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) are discussed based on recent reports, although the sensitization or desensitization mechanisms are not yet resolved. This review also briefly deals with the therapeutic use of capsaicin and its agonist and antagonist for relief pain. Whether or not capsaicin-sensitive nerve fibers are involved in itching is examined by recent literature survey. TRPV1-expressing nerve fibers were recently reported to be responsible for the itching sensation. Then, we proposed putative three possible itching pathways. The participation of pure sensoty nervefibers which exclusively transmit itchiness has not been found, as yet.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
25
Issue
1
Start Page
1
End Page
10
Sort Key
1
Published Date
2012-01-31
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Oral Sciences