ID 104975
タイトルヨミ
カプサイシン ノ サヨウ ト ソノ レセプター TRPV1 オヨビ ソレラ ト カンレン スル コガタ イチジ チカク ニューロン ノ ガイカン
タイトル別表記
An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons
著者
樋浦, 明夫 徳島大学大学院ヘルスバイオサイエンス研究部口腔組織学分野 KAKEN研究者をさがす
キーワード
カプサイシン
ヒスタミン
痒み
TRPV1
資料タイプ
学術雑誌論文
抄録
The specific actions of capsaicin on the small primary afferent neurons with regard to neuogenic inflammation and plasma extravasation are examined in this review. First, a short history of the study of capsaicin is introduced from the viewpoint of the efferent function of capsaicin-sensitive nerve fibers. Agonist (resiniferatoxin) and antagonists (capsazepine and ruthenium red) of capsaicin are refened, to better understand the action of the drug. The significance of the discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) are discussed based on recent reports, although the sensitization or desensitization mechanisms are not yet resolved. This review also briefly deals with the therapeutic use of capsaicin and its agonist and antagonist for relief pain. Whether or not capsaicin-sensitive nerve fibers are involved in itching is examined by recent literature survey. TRPV1-expressing nerve fibers were recently reported to be responsible for the itching sensation. Then, we proposed putative three possible itching pathways. The participation of pure sensoty nervefibers which exclusively transmit itchiness has not been found, as yet.
掲載誌名
四国歯学会雑誌
ISSN
09146091
cat書誌ID
AN10050046
出版者
四国歯学会
25
1
開始ページ
1
終了ページ
10
並び順
1
発行日
2012-01-31
EDB ID
248202
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
歯学系