ID 106056
Author
Nakagawa, Takenobu Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
Sakashita, Naomi Department of Human Pathology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ohnishi, Koji Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
Komohara, Yoshihiro Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
Takeya, Motohiro Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
Keywords
large cell neuroendocrine carcinoma
gallbladder
imprint cytology
screening
Content Type
Journal Article
Description
Large cell neuroendocrine carcinoma (LCNEC) is a rare poorly differentiated carcinoma with neuroendocrine differentiation showing aggressive clinical behavior. We herein report a case of gallbladder LCNEC, which was difficult to differentiate from poorly differentiated adenocarcinoma. An imprint cytology was very useful for the final diagnosis in this case. A 56-year-old male with left exophthalmos was admitted to the hospital. Radiological examinations revealed the presence of a left gallbladder tumor with orbital metastasis. The histological diagnosis was poorly differentiated adenocarcinoma, and intensive chemoradiotherapy was administered. Unfortunately, the patient died of extensive metastases 36 months after the initial onset of symptoms. An autopsy revealed a tumor mass in the gallbladder associated with multiple liver and peritoneal metastases. Imprint cytology of the main tumor revealed cytological features of LCNEC, and additional histological examinations confirmed this diagnosis. Although performing a histological examination is important for making a final diagnosis, imprint cytology is powerful tool for differential diagnosis of LCNEC, especially in patients with carcinoma with poor differentiation.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
60
Issue
1-2
Start Page
149
End Page
153
Sort Key
149
Published Date
2013-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences