直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 106056
著者
ナカガワ, タケノブ Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
坂下, 直実 Department of Human Pathology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
オオニシ, コウジ Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
コモハラ, ヨシヒロ Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
タケヤ, モトヒロ Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
キーワード
large cell neuroendocrine carcinoma
gallbladder
imprint cytology
screening
資料タイプ
学術雑誌論文
抄録
Large cell neuroendocrine carcinoma (LCNEC) is a rare poorly differentiated carcinoma with neuroendocrine differentiation showing aggressive clinical behavior. We herein report a case of gallbladder LCNEC, which was difficult to differentiate from poorly differentiated adenocarcinoma. An imprint cytology was very useful for the final diagnosis in this case. A 56-year-old male with left exophthalmos was admitted to the hospital. Radiological examinations revealed the presence of a left gallbladder tumor with orbital metastasis. The histological diagnosis was poorly differentiated adenocarcinoma, and intensive chemoradiotherapy was administered. Unfortunately, the patient died of extensive metastases 36 months after the initial onset of symptoms. An autopsy revealed a tumor mass in the gallbladder associated with multiple liver and peritoneal metastases. Imprint cytology of the main tumor revealed cytological features of LCNEC, and additional histological examinations confirmed this diagnosis. Although performing a histological examination is important for making a final diagnosis, imprint cytology is powerful tool for differential diagnosis of LCNEC, especially in patients with carcinoma with poor differentiation.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
1-2
開始ページ
149
終了ページ
153
並び順
149
発行日
2013-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系