ID 106358
Author
Okada, Tsuyoshi Department of Anesthesia, Takamatsu Red Cross Hospital
Mita, Naoji Department of Anesthesiology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsuhisa, Munehide Diabetes Therapeutics and Research Center, the University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kitahata, Hiroshi Department of Dental Anesthesiology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shimada, Mitsuo Department of Digestive and Pediatric Surgery, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Oshita, Shuzo Department of Anesthesiology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
continuous blood glucose monitoring
intensive insulin therapy
liver transplantation
glucose toxicity
artificial endocrine pancreas
Content Type
Journal Article
Description
Background : The purpose of this study was to evaluate the usefulness of the closed-loop system (STG-22 ; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose in patients undergoing liver transplantation. Methods : Sixteen patients undergoing livingdonor liver transplantation were enrolled in this study. Glucose levels were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n=8) or a programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n=8). The target glucose level range was set at 80-150 mg/dl. Results : The mean and SD of blood glucose concentration during surgery (Glu-Ave and Glu-SD, respectively) for the programmed insulin group were lower than for the manual insulin group. The coefficient of variability (Glu-CV=Glu-SD×100 /Glu-Ave) for the programmed insulin group was also lower than for the manual insulin group (20.1±4.9% vs. 26.9±6.1% ; mean±SD). No hypoglycemia was detected in either group. Conclusion : The STG-22 closed-loop system is effective for maintaining strict blood glucose control during liver transplantation with minimal variability in blood glucose concentration.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
60
Issue
3-4
Start Page
205
End Page
212
Sort Key
205
Published Date
2013-08
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences
Oral Sciences