ID 106358
著者
オカダ, ツヨシ Department of Anesthesia, Takamatsu Red Cross Hospital
川人, 伸次 Department of Anesthesiology, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
箕田, 直治 Department of Anesthesiology, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
松久, 宗英 Diabetes Therapeutics and Research Center, the University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
北畑, 洋 Department of Dental Anesthesiology, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
島田, 光生 Department of Digestive and Pediatric Surgery, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
大下, 修造 Department of Anesthesiology, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
continuous blood glucose monitoring
intensive insulin therapy
liver transplantation
glucose toxicity
artificial endocrine pancreas
資料タイプ
学術雑誌論文
抄録
Background : The purpose of this study was to evaluate the usefulness of the closed-loop system (STG-22 ; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose in patients undergoing liver transplantation. Methods : Sixteen patients undergoing livingdonor liver transplantation were enrolled in this study. Glucose levels were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n=8) or a programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n=8). The target glucose level range was set at 80-150 mg/dl. Results : The mean and SD of blood glucose concentration during surgery (Glu-Ave and Glu-SD, respectively) for the programmed insulin group were lower than for the manual insulin group. The coefficient of variability (Glu-CV=Glu-SD×100 /Glu-Ave) for the programmed insulin group was also lower than for the manual insulin group (20.1±4.9% vs. 26.9±6.1% ; mean±SD). No hypoglycemia was detected in either group. Conclusion : The STG-22 closed-loop system is effective for maintaining strict blood glucose control during liver transplantation with minimal variability in blood glucose concentration.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
3-4
開始ページ
205
終了ページ
212
並び順
205
発行日
2013-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院
先端酵素学研究所
歯学系