ID 109493
Author
Jin, Qing-Ri Department of Life Systems, Institute of Technology and Science, the University of Tokushima
Bandou, Yukiko Clinical Research Center for Diabetes, Tokushima University Hospital
Miyawaki, Katsuyuki Department of Life Systems, Institute of Technology and Science, the University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shikama, Yosuke Clinical Research Center for Diabetes, Tokushima University Hospital
Kosugi, Chisato Clinical Research Center for Diabetes, Tokushima University Hospital
Aki, Nanako Clinical Research Center for Diabetes, Tokushima University Hospital|Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, the University of Tokushima Graduate School
Funaki, Makoto Clinical Research Center for Diabetes, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Noji, Sumihare Diabetes Therapeutics and Research Center, the University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
FGF21
metabolic syndrome
triglycerides
systolic BP
biomarker
Content Type
Journal Article
Description
Objects : Since serum level of fibroblast growth factor 21 (FGF21) has been implicated as a potential biomarker for the early detection of the metabolic syndrome and type 2 diabetes, we examined how FGF21 serum levels are correlated with metabolic parameters in Japanese subjects. Methods : FGF21 levels were analyzed by enzyme-linked immunosorbent assays. Spearman’s correlation and multiple stepwise regression analyses were used to examine the relationship between serum FGF21 and other factors. A Mann-Whitney U test was performed between the normal and high groups for triglycerides and systolic blood pressure (BP) respectively. Results : By univariate correlation analysis, serum FGF21 levels were significantly associated with triglyceride levels, systolic BP, diastolic BP, pulse pressure, body mass index (BMI), age, fasting plasma glucose (FPG) levels, and total cholesterol levels. Multiple regression analysis (adjusted for age, gender, and BMI) showed that serum FGF21 levels were independently and significantly associated with triglyceride levels and systolic BP. Serum FGF21 levels were significantly higher in subjects with high triglyceride levels and high systolic BP compared with those who had normal triglyceride levels and normal systolic BP respectively. Conclusions : This study found that FGF21 levels might be a biomarker for some metabolic disorders associated with metabolic syndrome.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
61
Issue
1-2
Start Page
28
End Page
34
Sort Key
28
Published Date
2014-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry
University Hospital