アクセス数 : ?
ダウンロード数 : ?
ID 109493
著者
Jin, Qing-Ri Department of Life Systems, Institute of Technology and Science, the University of Tokushima
坂東, 由記子 Clinical Research Center for Diabetes, Tokushima University Hospital
宮脇, 克行 Department of Life Systems, Institute of Technology and Science, the University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
シカマ, ヨウスケ Clinical Research Center for Diabetes, Tokushima University Hospital
コスギ, チサト Clinical Research Center for Diabetes, Tokushima University Hospital
アキ, ナナコ Clinical Research Center for Diabetes, Tokushima University Hospital|Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, the University of Tokushima Graduate School
船木, 真理 Clinical Research Center for Diabetes, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
野地, 澄晴 Diabetes Therapeutics and Research Center, the University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
FGF21
metabolic syndrome
triglycerides
systolic BP
biomarker
資料タイプ
学術雑誌論文
抄録
Objects : Since serum level of fibroblast growth factor 21 (FGF21) has been implicated as a potential biomarker for the early detection of the metabolic syndrome and type 2 diabetes, we examined how FGF21 serum levels are correlated with metabolic parameters in Japanese subjects. Methods : FGF21 levels were analyzed by enzyme-linked immunosorbent assays. Spearman’s correlation and multiple stepwise regression analyses were used to examine the relationship between serum FGF21 and other factors. A Mann-Whitney U test was performed between the normal and high groups for triglycerides and systolic blood pressure (BP) respectively. Results : By univariate correlation analysis, serum FGF21 levels were significantly associated with triglyceride levels, systolic BP, diastolic BP, pulse pressure, body mass index (BMI), age, fasting plasma glucose (FPG) levels, and total cholesterol levels. Multiple regression analysis (adjusted for age, gender, and BMI) showed that serum FGF21 levels were independently and significantly associated with triglyceride levels and systolic BP. Serum FGF21 levels were significantly higher in subjects with high triglyceride levels and high systolic BP compared with those who had normal triglyceride levels and normal systolic BP respectively. Conclusions : This study found that FGF21 levels might be a biomarker for some metabolic disorders associated with metabolic syndrome.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
1-2
開始ページ
28
終了ページ
34
並び順
28
発行日
2014-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系
病院