ID 109522
Author
Niki, Hirobumi Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
Matsuzaki, Toshiya Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kinouchi, Riyo Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
Iwasa, Takeshi Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kawami, Takako Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
Kato, Takeshi Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kuwahara, Akira Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Irahara, Minoru Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
PCOS
testosterone
diagnosis
LH
assay
Content Type
Journal Article
Description
Hyperandrogenemia has become an important factor in the diagnosis of polycystic
ovary syndrome (PCOS), in Japan as well as Western countries, since the Japanese
PCOS diagnostic criteria were revised in 2007. The revised electrochemiluminescence immunoassay
(ECLIA) reagent for total testosterone (T) (ECLusys TESTO II ; New T assay),
which has lower cross-reactivity with DHEA-S than the previous reagent (ECLusys TESTO
I ; Old T assay), has recently been developed. We studied the improvement between New
and Old T assays in regards to the diagnostic performance of serum T for patients with
PCOS. Serum T levels were measured in both normal women (Control, n=92) and PCOS
patients (n=86). The rate of elevated T using each kit was significantly higher in the PCOS
group than in the Control group, and significantly higher using New T assay (38/86, 44.2%)
compared with Old T assay (26/86, 30.2%). A significant correlation was found between T
level and body mass index, but not LH level. Furthermore, higher detection rates of hormonal
abnormalities were seen in PCOS patients using combined measurement of both
T and LH (63/80) compared with single measurement of either T (37/80) or LH (36/80).
Therefore, the serum T assay is essential for the diagnosis of PCOS, and New T assay combined
with the LH assay may improve the diagnostic process for PCOS.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
61
Issue
1-2
Start Page
65
End Page
71
Sort Key
65
Published Date
2014-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital