ID 109522
著者
ニキ, ヒロブミ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
松崎, 利也 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キノウチ, リヨ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
岩佐, 武 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
カワミ, タカコ Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School
加藤, 剛志 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
桑原, 章 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
苛原, 稔 Department of Obstetrics and Gynecology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
PCOS
testosterone
diagnosis
LH
assay
資料タイプ
学術雑誌論文
抄録
Hyperandrogenemia has become an important factor in the diagnosis of polycystic
ovary syndrome (PCOS), in Japan as well as Western countries, since the Japanese
PCOS diagnostic criteria were revised in 2007. The revised electrochemiluminescence immunoassay
(ECLIA) reagent for total testosterone (T) (ECLusys TESTO II ; New T assay),
which has lower cross-reactivity with DHEA-S than the previous reagent (ECLusys TESTO
I ; Old T assay), has recently been developed. We studied the improvement between New
and Old T assays in regards to the diagnostic performance of serum T for patients with
PCOS. Serum T levels were measured in both normal women (Control, n=92) and PCOS
patients (n=86). The rate of elevated T using each kit was significantly higher in the PCOS
group than in the Control group, and significantly higher using New T assay (38/86, 44.2%)
compared with Old T assay (26/86, 30.2%). A significant correlation was found between T
level and body mass index, but not LH level. Furthermore, higher detection rates of hormonal
abnormalities were seen in PCOS patients using combined measurement of both
T and LH (63/80) compared with single measurement of either T (37/80) or LH (36/80).
Therefore, the serum T assay is essential for the diagnosis of PCOS, and New T assay combined
with the LH assay may improve the diagnostic process for PCOS.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
1-2
開始ページ
65
終了ページ
71
並び順
65
発行日
2014-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院