ID 109583
Author
Hosaka, Toshio Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School|Third Department of Internal Medicine, Kyorin University School of Medicine
Sasaga, Sayaka Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
Yamasaka, Yukiko Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
Nii, Yoshitaka Food Technology Division, Tokushima Prefectural Industrial Technology Center
Edazawa, Kazuhiro TANI FOOD Corporation, Ltd.
Tsutsumi, Rie Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
Shuto, Emi Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Okahisa, Naoki Food Technology Division, Tokushima Prefectural Industrial Technology Center
Iwata, Shinya Food Technology Division, Tokushima Prefectural Industrial Technology Center
Tomotake, Hiroyuki Iida Women’s Junior College
Sakai, Tohru Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
buckwheat
triglyceride
fatty liver
lypogenesis
Content Type
Journal Article
Description
Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-Ay mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of β-oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
61
Issue
3-4
Start Page
345
End Page
352
Sort Key
345
Published Date
2014-08
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences