ID 109583
著者
保坂, 利男 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School|Third Department of Internal Medicine, Kyorin University School of Medicine
ササガ, サヤカ Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
ヤマサカ, ユキコ Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
ニイ, ヨシタカ Food Technology Division, Tokushima Prefectural Industrial Technology Center
エダザワ, カズヒロ TANI FOOD Corporation, Ltd.
堤, 理恵 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
シュトウ, エミ Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
オカヒサ, ナオキ Food Technology Division, Tokushima Prefectural Industrial Technology Center
イワタ, シンヤ Food Technology Division, Tokushima Prefectural Industrial Technology Center
友竹, 浩之 Iida Women’s Junior College
酒井, 徹 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
buckwheat
triglyceride
fatty liver
lypogenesis
資料タイプ
学術雑誌論文
抄録
Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-Ay mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of β-oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
3-4
開始ページ
345
終了ページ
352
並び順
345
発行日
2014-08
EDB ID
296181
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系