ID 109614
Title Transcription
ナンジセイ コキュウキ シッカン ノ ブンシ ビョウタイ カイメイ ト シンキ チリョウホウ ノ カイハツ
Title Alternative
Analysis of molecular pathogenesis of lung cancer metastasis and pulmonary fibrosis for development of novel therapy
Author
Nishioka, Yasuhiko Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, the University of Tokushima Graduate School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
respiratory disease
lung cancer
metastasis
pulmonary fibrosis
fibroblast
Content Type
Journal Article
Description
Respiratory diseases include several intractable diseases such as lung cancer and pulmonary fibrosis. Particularly, lung cancer is a leading cause of death among various cancers. The reason why lung cancer shows poor prognosis could be due to early and multi-organ metastasis. We have performed the research to explore the mechanisms involved in the metastasis using multi-organ metastasis model in SCID mice, which enable us to study the organ-specific mechanism of metastasis. On the other hand, idiopathic pulmonary fibrosis (IPF) also shows the prognosis similar to lung cancer. The molecular pathogenesis in IPF is still unclear. Recent findings show the several origins of lung fibroblasts. Fibroblasts derived from circulating fibrocytes or epithelial-mesenchymal transition are thought to play a role in the fibrogenesis in the lungs. To analyze how these cells contribute to pulmonary fibrosis might lead to develop the novel therapy. Since many clinical trials are now going on worldwide for IPF, the forward and reverse translational research seems to be crucial to rapidly produce the outcome for patients.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
69
Issue
1-2
Start Page
51
End Page
56
Sort Key
51
Published Date
2013-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences