ID 109614
タイトルヨミ
ナンジセイ コキュウキ シッカン ノ ブンシ ビョウタイ カイメイ ト シンキ チリョウホウ ノ カイハツ
タイトル別表記
Analysis of molecular pathogenesis of lung cancer metastasis and pulmonary fibrosis for development of novel therapy
著者
西岡, 安彦 徳島大学大学院ヘルスバイオサイエンス研究部呼吸器・膠原病内科学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
respiratory disease
lung cancer
metastasis
pulmonary fibrosis
fibroblast
資料タイプ
学術雑誌論文
抄録
Respiratory diseases include several intractable diseases such as lung cancer and pulmonary fibrosis. Particularly, lung cancer is a leading cause of death among various cancers. The reason why lung cancer shows poor prognosis could be due to early and multi-organ metastasis. We have performed the research to explore the mechanisms involved in the metastasis using multi-organ metastasis model in SCID mice, which enable us to study the organ-specific mechanism of metastasis. On the other hand, idiopathic pulmonary fibrosis (IPF) also shows the prognosis similar to lung cancer. The molecular pathogenesis in IPF is still unclear. Recent findings show the several origins of lung fibroblasts. Fibroblasts derived from circulating fibrocytes or epithelial-mesenchymal transition are thought to play a role in the fibrogenesis in the lungs. To analyze how these cells contribute to pulmonary fibrosis might lead to develop the novel therapy. Since many clinical trials are now going on worldwide for IPF, the forward and reverse translational research seems to be crucial to rapidly produce the outcome for patients.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
69
1-2
開始ページ
51
終了ページ
56
並び順
51
発行日
2013-04-25
EDB ID
282006
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系