ID 109629
Title Transcription
コウド シンコウ カンサイボウ ガン ニ タイスル ホウシャセン ヘイヨウ ドウチュウ カガク リョウホウ ノ ユウヨウセイ
Title Alternative
Efficacy and safety of concurrent chemotherapy and radiotherapy for advanced hepatocellular carcinoma with extensive portal vein tumor thrombus
Author
Kobayashi, Naoto  The Post-graduate education Center, Tokushima University Hospital
Taniguchi, Tatsuya Department of Gastroenterology and Oncology, Tokushima University Hospital KAKEN Search Researchers
Miyamoto, Yoshihiko Department of Gastroenterology and Oncology, Tokushima University Hospital
Tanaka, Hiromichi Department of Gastroenterology and Oncology, Tokushima University Hospital
Tanaka, Takahiro Department of Gastroenterology and Oncology, Tokushima University Hospital Tokushima University Educator and Researcher Directory
Takaba, Azusa Department of Gastroenterology and Oncology, Tokushima University Hospital
Tomonari, Tetsu Department of Gastroenterology and Oncology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Harada, Rie Department of Gastroenterology and Oncology, Tokushima University Hospital
Sato, Momoko Department of Gastroenterology and Oncology, Tokushima University Hospital
Sannomiya, Katsutaka Department of Gastroenterology and Oncology, Tokushima University Hospital
Tamaki, Katsuyoshi Okubo Hospital
Takayama, Tetsuji Department of Gastroenterology and Oncology, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
hepatocellular carcinoma
portal vein tumor thrombus
MPT
5‐FU
IFN
radiotherapy
Content Type
Journal Article
Description
OBJECTIVE : The purpose of this study is to assess the treatment outcomes and adverse effects of concurrent chemotherapy and radiotherapy for hepatocellular carcinoma with portal vein tumor thrombus.
METHODS : Twelve unresectable hepatocellular carcinoma patients with portal vein tumor thrombosis were treated using concurrent chemotherapy and radiation therapy. Four patients received transcatheter arterial chemoembolization using miriplatin-lipiodol suspension. Eight patients received interferon-α (IFN) and 5‐fluorouracil (5‐FU) combination therapy. The total radiation dose was 30‐50Gy. The response rate and overall survival and the toxicity were analyzed.
RESULTS : Concurrent chemotherapy and radiotherapy was associated with a 50.0% objective response rate for primary tumors (miriplatin-lipiodol : 50.0%, IFN‐5FU : 50.0%). And a 66.7% objective response rate for portal vein tumor thrombus (miriplatin-lipiodol : 75.0%, IFN‐5FU : 62.5%). The median survival was 273 days (miriplatin-lipiodol : 273 days, IFN‐5FU : 262 days). Myelosuppression was observed in two patients, but no treatment-related deaths were observed.
CONCLUSIONS : The present results suggest concurrent chemotherapy and radiotherapy is a practical and safe treatment option in hepatocellular carcinoma patients with extensive portal vein tumor thrombus.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
69
Issue
3-4
Start Page
151
End Page
156
Sort Key
151
Published Date
2013-08-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences