ID 109649
Author
Iwata, T Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
Mizusawa, N Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
Taketani, Y Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Itakura, M Division of Genetic Information, Institute for Genome Research, The University of Tokushima
Yoshimoto, Katsuhiko Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
HRPT2
parafibromin
SV40 large T antigen
tumorigenesis
tumor suppressor
Content Type
Journal Article
Description
Parafibromin is a 531-amino acid protein encoded by HRPT2, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome and sporadic parathyroid carcinoma. To investigate effects of parafibromin's overexpression on cell proliferation, we performed assays in four different cell lines. The transient overexpression of parafibromin inhibited cell growth in HEK293 and NIH3T3 cells, but enhanced cell growth in the SV40 large T antigen expressing-cell lines such as 293FT and COS7 cells. In 293FT cells, parafibromin was found to interact with SV40 large T antigen and its overexpression promoted entry into the S phase, implying that the interaction enhanced progression through the cell cycle. The tumor suppressor protein parafibromin acts as a positive regulator of cell growth like an oncoprotein in the presence of SV40 large T antigen.
Journal Title
Oncogene
ISSN
09509232
NCID
AA10687380
Volume
26
Issue
42
Start Page
6176
End Page
6183
Sort Key
6176
Published Date
2007-09-13
Remark
© 2007 Nature Publishing Group All rights reserved
EDB ID
Published Source
Oncogene (2007) Volume 26 Issue 42 p.6176–6183 (doi:10.1038/sj.onc.1210445)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Oral Sciences