アクセス数 : ?
ダウンロード数 : ?
ID 109649
著者
Iwata, T Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
Mizusawa, N Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
Taketani, Y Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Itakura, M Division of Genetic Information, Institute for Genome Research, The University of Tokushima
吉本, 勝彦 Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
HRPT2
parafibromin
SV40 large T antigen
tumorigenesis
tumor suppressor
資料タイプ
学術雑誌論文
抄録
Parafibromin is a 531-amino acid protein encoded by HRPT2, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome and sporadic parathyroid carcinoma. To investigate effects of parafibromin's overexpression on cell proliferation, we performed assays in four different cell lines. The transient overexpression of parafibromin inhibited cell growth in HEK293 and NIH3T3 cells, but enhanced cell growth in the SV40 large T antigen expressing-cell lines such as 293FT and COS7 cells. In 293FT cells, parafibromin was found to interact with SV40 large T antigen and its overexpression promoted entry into the S phase, implying that the interaction enhanced progression through the cell cycle. The tumor suppressor protein parafibromin acts as a positive regulator of cell growth like an oncoprotein in the presence of SV40 large T antigen.
掲載誌名
Oncogene
ISSN
09509232
cat書誌ID
AA10687380
26
42
開始ページ
6176
終了ページ
6183
並び順
6176
発行日
2007-09-13
備考
© 2007 Nature Publishing Group All rights reserved
EDB ID
出典
Oncogene (2007) Volume 26 Issue 42 p.6176–6183 (doi:10.1038/sj.onc.1210445)
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系